I may recommend cortisone for your hip, knee, or your shoulder. Cortisone is a very strong anti-inflammatory, almost like a super Ibuprofen. The difference is that it is injected right into the joint. Typically this includes numbing medication that works immediately in the injured area. It actually helps us make a diagnosis. Then it will wear off in four to five hours. You may be sore for a couple of days. The cortisone will take effect in three to five days, and typically will take up to two weeks to have its maximum effect.